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Functional masking of carbonyl group by 1-methyl-1H-imidazol-2-YL moiety

✍ Scribed by Shunsaku Ohta; Satoshi Hayakawa; Kazuko Nishimura; Masao Okamoto

Book ID: 104242215
Publisher: Elsevier Science
Year: 1984
Tongue: French
Weight: 261 KB
Volume: 25
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)91023-8

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## Abstract magnified image Oxidation of metronidazole (**4**) with sodium dichromate yielded the corresponding 2‐(2‐methyl‐5‐nitro‐1__H__‐imidazol‐1‐yl)acetic acid (**5**) which was esterified with 1‐butanol to give butyl 2‐(2‐methyl‐5‐nitro‐1__H__‐imidazol‐1‐yl)acetate (**8**). Reaction of the l