✦ LIBER ✦

Functional magnetic resonance imaging of median nerve stimulation in rats at 2.0 T

✍ Scribed by B. Ellen Scanley; Richard P. Kennan; Susan Cannan; Pawel Skudlarski; Robert B. Innis; John C. Gore

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 442 KB
Volume: 37
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910370625

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

An animal model of sensory activation using fMRI at 2.0 T has been developed, demonstrating that fMRI studies on animals need not be limited to high field magnets. These methods produced reliable image intensity changes of 2% using median nerve stimulation in rats at 3 Hz and propofol as the anesthetic agent. At 6 Hz the activation was slightly but not statistically significantly greater. The feasibility of fMRI studies in animals using propofol suggests that it may be a useful anesthetic for fMRI studies in agitated adult patients or in children.

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