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Functional intracellular P-glycoprotein

✍ Scribed by Adam B. Shapiro; Kelly Fox; Pat Lee; Yvonne D. Yang; Victor Ling

Book ID
101236102
Publisher
John Wiley and Sons
Year
1998
Tongue
French
Weight
362 KB
Volume
76
Category
Article
ISSN
0020-7136

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The intracellular pH (pH(i)) of cells exhibiting multidrug resistance (MDR) related to the expression of the P-glycoprotein (Pgp) is often more alkaline than that of the parental cells, as also observed for the KB-V1/KB-3-1 system in this paper. The possible role of an elevated pH(i) in Pgp-related