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Functional Modulation of ATPase of P-Glycoprotein by C219, a Monoclonal Antibody against P-Glycoprotein

✍ Scribed by Noriko Kokubu; Dalia Cohen; Toru Watanabe


Book ID
115579660
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
307 KB
Volume
230
Category
Article
ISSN
0006-291X

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The role of P-glycoprotein in mediating the drug-resistance phenotype in multidrug resistant cells is now well documented. It is thought to function as an energy-dependent drug-efflux pump of broad specificity. Structurally, P-glycoprotein is an internally duplicated molecule containing two large mu