Modulation of ATP and drug binding by mo
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Elias Georges; Jian-Ting Zhang; Victor Ling
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Article
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1991
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John Wiley and Sons
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English
β 719 KB
The role of P-glycoprotein in mediating the drug-resistance phenotype in multidrug resistant cells is now well documented. It is thought to function as an energy-dependent drug-efflux pump of broad specificity. Structurally, P-glycoprotein is an internally duplicated molecule containing two large mu