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Functional interaction between the epidermal growth factor receptor and c-Src kinase activity

โœ Scribed by Paschal A. Oude Weernink; Astrid E. Ottenhoff-Kalff; Marijke P. Vendrig; Ellen A.C.M. van Beurden; Gerard E.J. Staal; Gert Rijksen


Book ID
115929430
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
696 KB
Volume
352
Category
Article
ISSN
0014-5793

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In C3H/10T1/2 murine fibroblasts, overexpression of both c-Src and the human epidermal growth factor (EGF) receptor 1 (HER1) is required for detection of stable complexes between the two molecules and results in hyperactivation of the receptor and synergistic increases in tumor formation in nude mic