✦ LIBER ✦

Functional imaging of the rat cervical spinal cord

✍ Scribed by Krisztina L. Malisza; Patrick W. Stroman

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 663 KB
Volume: 16
Category: Article
ISSN: 1053-1807
DOI: 10.1002/jmri.10185

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Purpose:

To examine functional magnetic resonance imaging (fMRI) of the rat cervical spinal cord using painful stimulation.

Materials and Methods:

fMRI of the rat cervical spinal cord was performed at 9.4 T. Stimuli included injection of 25μL of capsaicin (128 μg/mL in 7.5% dimethylsulfoxide (DMSO)) into the right dorsal forepaw and electrical stimulation (15 V, 0.3 msec, 3 Hz) of the left dorsal forepaw.

Results:

Activation in the dorsal horn of the spinal cord, which is known to be associated with the transmission of pain, was found in all rats (N = 4) following injection of capsaicin into the dorsal forepaw. It was possible to reproduce the pain response in a given animal several times throughout the course of an experiment, provided that sufficient time was allowed between capsaicin injections. Regions of the spinal cord associated with motor and pain response were observed in functional imaging experiments involving subcutaneous electrical stimulation of the dorsal forepaw.

Conclusion:

Spinal fMRI using electrical stimulation and capsaicin‐induced painful stimulation can be a useful tool in an animal model of pain and injury. J. Magn. Reson. Imaging 2002;16:553–558. © 2002 Wiley‐Liss, Inc.

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