Functional group contribution in ion-pair extraction of tricyclic amines

✍ Scribed by Ho-Leung Fung; Yim-Hing Ow

• Book ID: 102403234
• Publisher: John Wiley and Sons
• Year: 1972
• Tongue: English
• Weight: 420 KB
• Volume: 61
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600611217

✦ Synopsis

The use of ion-pair extraction data to obtain group contribution values necessitates an assumption of countcrion independency. This assumption was examined in the present study, using the extraction of four tricyclic antidepressants with several anions as examples. It was found t o be valid, and a consistent relative functional group value could be obtained when substitution on the tricyclic amines was distant from the charged center. However, when substitution was a t the charged center, as exemplified by comparison of the methylated and demethylated antidepressants, the observed group contribution value was anion dependent.