Functional evaluation of glutamate receptor subtypes in cultured cerebellar neurones and astrocytes
β Scribed by Vittorio Gallo; Rossana Suergiu; Giulio Levi
- Book ID
- 115880852
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 352 KB
- Volume
- 138
- Category
- Article
- ISSN
- 0014-2999
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π SIMILAR VOLUMES
## Abstract Several excitatory amino acid ligands were found potently to inhibit forskolinβstimulated cAMP accumulation in rat cultured cerebellar astrocytes: Lβcysteine sulfinic acid (LβCSA) = Lβaspartate > Lβglutamate β₯ the glutamate uptake inhibitor, LβPDC. This property did not reflect activati
Cultured astrocytes from neonatal rat cerebral hemispheres are depolarized by the excitatory neurotransmitter glutamate. In this study we have used selective agonists of different neuronal glutamate receptor subtypes, namely, the N-methyl-D-aspartate (NMDA), kainate, and quisqualate type, to charact