Functional deficiencies of components of the MHC class I antigen pathway in human tumors of epithelial origin
β Scribed by Delp, K; Momburg, F; Hilmes, C; Huber, C; Seliger, B
- Book ID
- 110012541
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 128 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0007-1188
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## Abstract Previous reports from our group indicated that the MHC class I phenotype of metastatic lung colonies produced by a mouse fibrosarcoma tumor clone (B9) were, depending on the immune status of the host, MHC class I negative in immunocompetent mice and MHC class I positive in immunodeficie
The level of expression of the class-I major histocompatibil-19 and 54kDa. The El region encompasses those viral genes ity (MHC) antigen was determined in a series of human em-expressed first following lytic infection and is also that area bryo cell lines transformed with either adenovirus I2 (Ad 12
Expression of major histocompatibility complex (MHC) class I antigens was induced in eight out of nine freshly prepared tumor cell suspensions by exposure to interferon (IFN gamma) and tumor necrosis factor (TNF alpha) in vitro. The untreated, class-I-antigen-negative, and the treated, antigen-posit