✦ LIBER ✦

Functional decline in Huntington's disease

✍ Scribed by Dr. Andrew Feigin; Karl Kieburtz; Kathy Bordwell; Peter Como; Kimberly Steinberg; Jenny Sotack; Carol Zimmerman; Charlyne Hickey; Constance Orme; Ira Shoulson

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 312 KB
Volume: 10
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.870100213

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

We prospectively evaluated 129 patients with manifest Huntington's disease (HD) to determine the rate of illness progression and the clinical features that correlate with functional decline. A single examiner evaluated each patient using the HD Functional Capacity Scale. Standardized motor performance was also assessed in 94 of the patients (73%) using the HD Rating Scale. Total Functional Capacity declined at a rate of 0.63 ± 0.75 U per year. As functional capacity worsened, chorea lessened, and dystonia intensified. There was no correlation between rate of functional decline and age at onset of HD, body weight, gender of affected parent, or history of neuroleptic use.

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