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Functional D4 polymorphism in schizophrenics treated with clozapine

✍ Scribed by Shaikh, S.; Kerwin, R.; Collier, D.; Launer, M.; Pilowsky, L.; Munro, J.; Gill, M.

Book ID
122561434
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
112 KB
Volume
9
Category
Article
ISSN
0920-9964

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## Abstract We have examined the hypothesis that a variable number of tandem repeats in the third cytoplasmic loop of the dopamine D4 receptor influences clinical response to clozapine using a sample of 189 schizophrenic patients. Alleles of the 48‐bp repeat, which range from two to ten copies in t