Functional consequences of over-expressing the gap junction Cx43 in the cardiogenic potential of pluripotent human embryonic stem cells

Inducible expression of the gap junction

Inducible expression of the gap junction protein connexin43 decreases the neoplastic potential of HT-1080 human fibrosarcoma cells in vitro and in vivo

✍ Timothy J. King; Laurie H. Fukushima; Yutaka Yasui; Paul D. Lampe; John S. Bertr 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 264 KB

## Abstract Numerous studies have demonstrated a correlation between dysregulation/loss of connexin expression or gap junction intercellular communication (GJIC) function and decreased growth control both in human tumors and tumor cell lines. Likewise, restoration of constitutive connexin expressio