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Functional class switch recombination may occur ‘in vivo’ in Waldenström macroglobulinaemia

✍ Scribed by Patricia Martín-Jiménez; Ramón García-Sanz; María E. Sarasquete; Enrique Ocio; José J. Pérez; Marcos González; Jesús F. San Miguel

Book ID: 108674049
Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 464 KB
Volume: 136
Category: Article
ISSN: 0007-1048
DOI: 10.1111/j.1365-2141.2006.06397.x

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## Abstract Ig class switch recombination (CSR) is dependent upon the expression of activation‐induced deaminase and targeted to specific isotypes by germ‐line transcript expression and isotype‐specific factors. NF‐κB plays critical roles in multiple aspects of B cell biology and has been implicate