Functional assays of HLA A2-restricted epitope variant of latent membrane protein 1 (LMP-1) of Epstein-Barr virus in nasopharyngeal carcinoma of Southern China and Taiwan
✍ Scribed by Hsiang-Ju Lin; Jaw-Ming Cherng; Man-Shan Hung; Yiyang Sayion; Jung-Chung Lin
- Publisher
- BioMed Central
- Year
- 2005
- Tongue
- English
- Weight
- 339 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1021-7770
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## Abstract ## Background Nasopharyngeal carcinoma (NPC) is associated with Epstein–Barr virus (EBV) infection. We previously found that interleukin (IL)‐1α and IL‐1β significantly increased in NPC tissues. This study investigated what EBV‐encoded proteins were involved in such IL‐1 production. #
## Abstract Nasopharyngeal carcinoma is closely associated with Epstein‐Barr virus (EBV) and the EBV encoded latent membrane protein‐1 expression (LMP1) is commonly found in the tumour cells. LMP1 has been shown to be involved in modulation of cell growth in B cells but the biological properties of
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## Abstract Latent membrane protein 1 (LMP‐1) is an Epstein‐Barr virus‐encoded oncoprotein expressed in ∼50–70% of nasopharyngeal carcinoma (NPC). Previous studies have shown that NPC‐derived LMP‐1 variants carrying 30 bp deletion and specific mutations in the 3′C‐terminal region confer high oncoge