Functional analysis of the phenobarbital-responsive unit in rat CYP2B2
β Scribed by Siqing Liu; Ilia Rivera-Rivera; Andrew J Bredemeyer; Byron Kemper
- Book ID
- 113992669
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 279 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0006-2952
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The mouse __Cyp2bβ10__ gene is inducible by treatment with estradiol as well as soβcalled phenobarbital (PB)βlike inducers. To identify 5β²βflanking elements responsible for induction by estradiol, we carried out reporter gene assays using a primary mouse hepatocyte culture system. __Cyp
xenobiotics (2). As a result, metabolism by CYP enzymes can result in activation of xenobiotics to more toxic and carcinogenic products. CYPs, therefore, can be viewed as "environmental friends and foes.
## Abstract Potential mechanisms were investigated whereby __CYP2B18__, a cytochrome P450 gene exhibiting high constitutive expression but only low levels of phenobarbitalβinducibility in the guinea pig liver, may be differentially regulated versus the highly inducible rat __CYP2B2__ gene. To compa