Phenobarbital induces liver cytochrome P-450 b,e proteins mainly by increasing the rate of transcription of these genes. The mechanism responsible for the phenobarbital increment in the rate of transcription of cytochrome P-450 b,e genes is unknown. The objective of this study was to assess whether
Regulatory DNA elements of phenobarbital-responsive cytochrome P450 CYP2B genes
β Scribed by Paavo Honkakoski; Masahiko Negishi
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 108 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1095-6670
No coin nor oath required. For personal study only.
β¦ Synopsis
xenobiotics (2). As a result, metabolism by CYP enzymes can result in activation of xenobiotics to more toxic and carcinogenic products. CYPs, therefore, can be viewed as "environmental friends and foes.
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