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Functional analysis of human microsomal epoxide hydrolase genetic variants

✍ Scribed by Vinayak P. Hosagrahara; Allan E. Rettie; Christopher Hassett; Curtis J. Omiecinski

Book ID
113517065
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
152 KB
Volume
150
Category
Article
ISSN
0009-2797

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## Abstract The carcinogenic effects of 1,3‐butadiene (BD), a chemical widely used in the rubber industry, are thought to be due to its epoxide metabolites. In humans, these epoxides are detoxified predominantly by hydrolysis, a reaction mediated by the microsomal epoxide hydrolase (mEH) enzyme. Th