Function of ileal J pouch-anal anastomosis in patients with familial adenomatous polyposis
β Scribed by C. Penna; E. Tiret; A. Kartheuser; L. Hannoun; B. Nordlinger; Professor R. Parc
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 337 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0007-1323
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
Pouch function after proctocolectomy and ileal J pouch-anal anastomosis was assessed at 1 and 5 years in 41 patients with familial adenomatous polyposis. The mean(s.d.) stool frequency per 24 h decreased from 4Β·4(1Β·7) to 3Β·9(1Β·8) (P < 0Β·05), the mean(s.d.) nocturnal stool frequency fell from 0Β·6(1Β·0) to 0Β·3(0Β·6) (P < 0Β·05), and the number of patients having nocturnal bowel movements decreased from 16 to seven (P < 0Β·05). At 5 years, only one patient still followed a strict diet (versus ten at 1 year, P < 0Β·05) and only two needed antidiarrhoeal medication (versus ten at 1 year, P < 0Β·05). There were no episodes of pouchitis or late reservoir-related complications. The function of ileal pouch-anal anastomosis improves over time in patients with familial adenomatous polyposis.
π SIMILAR VOLUMES
Familial adenomatous polyposis (FAP) represents a human model of the adenomasarcinoma sequence. Colectomy substantially reduces the cancer risk. Restorative proctocolectomy maintains continence and abolishes the risk of rectal cancer, but there is a price to pay in terms of an increased morbidity ra