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Function for p300 and not CBP in the apoptotic response to DNA damage

โœ Scribed by Yuan, Zhi-Min; Huang, Yinyin; Ishiko, Takatoshi; Nakada, Shuji; Utsugisawa, Taiju; Shioya, Hisashi; Utsugisawa, Yukari; Shi, Yang; Weichselbaum, Ralph; Kufe, Donald


Book ID
110062329
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
208 KB
Volume
18
Category
Article
ISSN
0950-9232

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p53 apoptotic response to DNA damage dep
โœ David L. Crowe; Uttam K. Sinha ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 286 KB ๐Ÿ‘ 1 views

Background. In many tumors, the p53 gene has been mutated or deleted. p53 null mutant mice are prone to development of a variety of neoplasms at an early age. In head and neck cancer, p53 mutations are detected in most cases. p53 has been shown to induce growth arrest, differentiation, and death whe