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Fulminant human herpesvirus six encephalitis in a human immunodeficiency virus-infected infant

✍ Scribed by Konstance K. Knox; Daniel P. Harrington; Donald R. Carrigan

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
624 KB
Volume
45
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

Self‐limited involvement of the central nervous system (CNS) is a relatively common complication of primary infection with human herpesvirus six (HHV‐6) in normal children. We describe an HIV‐infected infant who developed fulminant encephalitis as a complication of HHV‐6 infection. Immunohistochemical staining of CNS tissue demonstrated productive infection of all CNS cell‐types. Analysis of the infected brain tissue by the polymerase chain reaction (PCR) confirmed the presence of a dense HHV‐6 infection in the tissue, and demonstrated that the virus present in the CNS tissue was predominantly the A variant of HHV‐6. This is the first demonstration of invasive tissue disease caused by HHV‐6 in an HIV‐infected infant. © 1995 Wiley‐Liss, Inc.

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