MITSURU YASUNAGA,' KrwAMu OKITA,' SHUNICHI S A T O , ~ TOSHIHIKO TAKEUCHI,~ KATSUHIKO TSUKADA,~ To determine the risk of death at an early stage of fulminant viral hepatitis, we created severity indexes drawn from clinical data on the day of development of encephalopathy in 128 patients with fulmina
Fulminant epstein-barr viral hepatitis: Orthotopic liver transplantation and review of the literature
โ Scribed by Feranchak, Andrew P. ;Tyson, R. Weslie ;Narkewicz, Michael R. ;Karrer, Frederick M. ;Sokol, Ronald J.
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1998
- Tongue
- English
- Weight
- 623 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1074-3022
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โฆ Synopsis
Acute hepatic failure caused by primary Epstein-Barr virus (EBV) infection has been reported in the literature in 16 cases, with an overall mortality of 87%. We report a case of fulminant hepatic failure in an immunocompetent young girl caused by primary EBV infection that was treated by orthotopic liver transplantation. After transplantation she has been treated with low-dose immuno-suppression, a pooled gammaglobulin preparation containing anti-EBV antibodies, and anti-viral therapy. The patient is presently doing well 2 years after transplantation without evidence of clinical EBV infection, primary immunodeficiency, or lymphoproliferative disease.
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