Viral dynamics of hepatitis C early after orthotopic liver transplantation: Evidence for rapid turnover of serum virions
✍ Scribed by T Fukumoto; T Berg; Y Ku; W O Bechstein; M Knoop; H Lemmens; H Lobeck; U Hopf; P Neuhaus
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 160 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0270-9139
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✦ Synopsis
rum HCV-RNA levels in recipients before, during, and after The pathogenesis of hepatitis C virus (HCV) infection
OLT to obtain kinetic information on the dynamics of HCV is likely to be associated with viral replication in vivo, replication and clearance in vivo. Liver transplantation recipbut little is known concerning the dynamics of HCV ients are ideally suited to provide insights into the mechaturnover. We performed serial measurements of serum nisms of HCV pathogenesis, because hepatic HCV replication HCV-RNA levels following orthotopic liver transplantais terminated at the time of removal of the infected liver, and tion (OLT) in nine patients with HCV-positive cirrhosis.
the clinical setting following reperfusion of the engrafted liver Serum HCV-RNA levels were determined by quantitaprovides a model for monitoring dynamic processes of graft tive polymerase chain reaction before, immediately reinfection. after, and for up to 1 month after OLT. There was a rapid decline in HCV-RNA levels from 3.1 { 1.3 1 10 5 copies/ PATIENTS AND METHODS mL (mean { SEM) preoperatively to 0.15 { 0.6 1 10 5 copies/mL on the first and 0.16 { 0.6 1 10 5 copies/mL on the Nine consecutive patients (8 males; median age, 40 y, range, 27 second postoperative day (mean viral half-life, 4.0 { 0.5 to 62 y) who underwent OLT for decompensated HCV-induced cirrho- h). Thereafter, HCV-RNA levels increased in all but one sis at