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Fully automated one-pot synthesis of [18F]fluoromisonidazole

✍ Scribed by Ganghua Tang; Mingfang Wang; Xiaolan Tang; Manquan Gan; Lei Luo


Book ID
116798871
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
320 KB
Volume
32
Category
Article
ISSN
0969-8051

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A rapid, one-pot synthesis of [isF]fluoromisonidazole (1H-l-(3-[isF]fluoro-2hydroxypropyl)-2-nitroimidazole) (1) starting from ['sF]fluoride and (2R)-(-)-glycidyl tosylate (2) is described. The total time required for the synthesis, the radiochemical yield, and purity of the titled compound are ca.