From Coded to Non-Coded α-Amino Acids: A Journey in Oligopeptide Stereochemistry
✍ Scribed by Claudio Toniolo
- Book ID
- 101978102
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 8 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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Single crystal X-ray diffraction study reveals that the water soluble tetrapeptide H 2 N-Ile-Aib-Leu-m-ABA-CO 2 H, containing non-coded Aib (a-amino isobutyric acid) and m-ABA (meta-amino benzoic acid), crystallizes with two smallest possible diastereomeric b-hairpin molecules in the asymmetric unit
The model tripeptide Boc-Leu(1)-Aib(2)-Phe(3)-OMe 1 containing a non-coded amino acid residue (Aib: a-amino isobutyric acid) forms a supramolecular helical assemblage via non-covalent interactions in single crystals. The SEM image of the peptide 1 in the solid state shows the ribbon like fibrillar m