✦ LIBER ✦

First crystallographic signature of the highly ordered supramolecular helical assemblage from a tripeptide containing a non-coded amino acid

✍ Scribed by Debasish Haldar; Samir Kumar Maji; William S Sheldrick; Arindam Banerjee

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 193 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)00283-6

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✦ Synopsis

The model tripeptide Boc-Leu(1)-Aib(2)-Phe(3)-OMe 1 containing a non-coded amino acid residue (Aib: a-amino isobutyric acid) forms a supramolecular helical assemblage via non-covalent interactions in single crystals. The SEM image of the peptide 1 in the solid state shows the ribbon like fibrillar morphology, a characteristic feature of highly ordered aggregated fibrils like amyloid fibrils.

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