𝔖 Scriptorium
✦   LIBER   ✦

📁

From Basic to Clinical Immunology

✍ Scribed by Vladimir V. Klimov


Publisher
Springer
Year
2019
Tongue
English
Leaves
391
Edition
1st ed. 2019
Category
Library

⬇  Acquire This Volume

No coin nor oath required. For personal study only.

✦ Synopsis


This book fills a gap at the interface of fundamental and clinical immunology, and allergy. For many years, experts in fundamental immunology and physicians involved in clinical immunology and allergy worked separately – but the fundamental immunologists did not have medical qualifications and the physicians were not involved in the field of fundamental research. Written by a teacher and an expert in both fields, this book combines current knowledge on basic immunology and immunopathology with clinical comments that complete the whole picture.

Immunology is a complex science, which requires a simplified approach in order to be taught and understood effectively. This book is based on the authors’ long experience in teaching undergraduate, postgraduate students and interns both basic and clinical immunology.

Reviewing a variety of important components related to the immune system, it is clearly and logically structured, and enriched by figures, tables and boxes with important immunology definitions. Each chapter has its own bibliography, and most units include links to electronic quizzes and audio files to accompany readers step by step. This easy-to-follow volume concludes with suggestions for future study. It is a valuable resource for undergraduate and postgraduate students, as well as medical practitioners.

✦ Table of Contents


Preface
Acknowledgments
Contents
About the Author
List of Abbreviations
List of Videos
1: Functional Organization of€the€Immune System
1.1 Introduction
1.2 Antigens and “Patterns”
1.3 Immunological Mechanisms
1.3.1 Innate Immunity
1.3.2 Adaptive Immunity
1.4 Organization of the mmune System at a
Glance
1.5 Molecules of the
Immune System
1.5.1 Antigen-Recognizing and
Antigen-Binding Molecules
1.5.1.1 Immunoglobulins
1.5.1.2 Fc Receptors
1.5.1.3 B-cell Receptors (BCR)
1.5.1.4 T-Cell Receptors (TCR)
1.5.1.5 Human Leukocyte Antigens (HLA)
1.5.2 Pattern Recognition Receptors (PRRs)
1.5.3 Cell Adhesion Molecules (CAM)
1.5.4 Cytokines
1.5.4.1 Interleukins (ILs)
1.5.4.2 Colony-Stimulating Factors (CSFs)
1.5.4.3 Interferons (IFNs)
1.5.4.4 Tumor Necrosis Factors (TNFs)
1.5.4.5 Cytokine Receptors
1.5.5 Chemokines
1.5.5.1 Chemokine Receptors
1.6 Organs of€the€Immune System
1.6.1 The Thymus
1.6.2 The Bone Marrow
1.6.3 The Spleen
1.6.4 The Lymph Nodes
1.7 Cells of€the€Immune System
1.7.1 Lymphocytes
1.7.2 T Cells and€T Lymphopoiesis
1.7.3 B Cells and€B Lymphopoiesis
1.7.4 Burnet’s Clonal Selection Theory
1.7.5 Innate Lymphoid Cells (ILCs)
1.7.6 Dendritic Cells
1.7.7 Monocytes and€Macrophages
1.7.8 Neutrophils
1.7.9 Eosinophils
1.7.10 Basophils and€Mast Cells
Bibliography
Reviews
Landmark Papers
Suggested Reading
2: Skin and€Mucosal Immune System
2.1 Introduction
2.2 Compartments of€the€Skin and€Mucosal Immune System
2.2.1 Inductive and€Secretory Effector Sites of€MALT
2.3 Upper and€Lower Respiratory Tract and€Conjunctives
2.4 Mouth and Gastrointestinal and
Genitourinaty Tracts
2.4.1 Mouth
2.4.2 Gastrointestinal Tract
2.4.3 Genitourinary Tract
2.5 Skin
Bibliography
Reviews
Landmark Papers
Suggested Reading
3: Innate Immunity
3.1 Introduction
3.2 Pattern Recognition Theory
3.3 “Acute Phase” Proteins
3.3.1 Pro-inflammatory “Acute Phase” Proteins
3.3.2 Anti-inflammatory “Acute Phase” Proteins
3.4 The Complement System
3.4.1 Classical Pathway
3.4.2 Alternative Pathway
3.4.3 Regulatory Proteins of€the€Complement
3.4.4 Complement Receptors
3.5 Phagocytosis
3.6 NETosis
3.7 Natural Cytotoxicity
3.7.1 Interferons (IFNs)
3.7.2 NK Cells
3.7.3 NK-Cell Subsets
3.8 Inflammasome, Pyroptosis, and€Physiological Inflammation
Bibliography
Reviews
Landmark Papers
Suggested Reading
4: Adaptive Immune Responses
4.1 Introduction
4.2 Pathways and€Stages of€Adaptive Immune Responses
4.3 Antigen Processing
4.4 “Dual Recognition” and Other Signals
4.4.1 Type 1 Helper T-Cell-Dependent Pathways
4.4.2 Type 2 Helper T Cells/Follicular Helper T-Cell-Dependent Pathway
4.5 Signaling and€Lymphocyte Activation
4.6 Clonal Expansion
4.7 Lymphocyte Differentiation in€the€Course of Immune€Responses
4.7.1 Memory Cells
4.8 Effector Activity
4.9 Regulation of
Immune Responses
4.9.1 The Idiotype/Anti-idiotype Network
4.9.2 Natural T-Regulatory Cells
4.9.3 Adaptive Helper T Cells
4.9.4 Hepatic and€Metabolic Control
4.9.5 Neuroendocrine Regulation
4.9.6 Genetic Regulation
4.9.7 Generation of€Effector Molecule Diversity
4.9.8 Generation of€the€Power of€Immune Responses
4.10 Immune Tolerance
4.10.1 Oral Tolerance
Bibliography
Reviews
Landmark Papers
Suggested Reading
5: Immunological and€Molecular Biological€Methods
5.1 Introduction
5.2 Flow Cytofluorometry
5.3 Enzyme-Linked Immunosorbent Assay (ELISA)
5.4 Immunoblot (Western Blot)
5.5 Radioimmunoassay (RIA)
5.6 Immunohistochemistry Staining
5.7 Cell Proliferation Assays
5.8 Cytotoxicity Assays
5.9 Tests on€Phagocytosis
5.10 Molecular Biological Methods
5.11 Clinical Assessment of€Immunoassays
Bibliography
Reviews
Landmark Papers
Suggested Reading
6: Immunopathology
6.1 Introduction
6.2 Immunodeficiencies
6.3 HIV/AIDS
6.4 Allergic Disorders
6.4.1 Type I
6.4.2 Type II
6.4.3 Type III
6.4.4 Type IV
6.5 Autoimmune and€Autoinflammatory Disorders
6.6 Immunology of€Cancer
6.7 Immunology of€Graft Rejection and€Survival
Bibliography
Reviews
Landmark Papers
Suggested Reading
7: Immunology of€Infectious Processes
7.1 Introduction
Bibliography
Reviews
Landmark Papers
Suggested Reading
8: Vaccination
8.1 Introduction
Bibliography
Reviews
Landmark Papers
Suggested Reading
9: Immune Enhancement Therapy
9.1 Introduction
9.2 Products of€the€Thymus and€Spleen
9.2.1 TFX-Thymomodulin®
9.2.2 Thymex-L®
9.2.3 Splenin®
9.3 Immunoglobulin Therapy
9.3.1 Octagam® (Human Immune Globulin G)
9.4 Recombinant Cytokines
9.4.1 Proleukin® (Aldesleukin, a€Human Recombinant Interleukin-2 Product)
9.4.2 Viferon® (A Human Recombinant Interferon α2b Product)
9.5 Synthetic Products
9.5.1 Ampligen® (Rintatolimod)
9.5.2 Cycloferon® (Meglumine Acridonacetate)
9.5.3 Polyoxidonium® (Azoximer Bromide)
9.6 Mucosal Autovaccines
9.6.1 Ismigen®, Immubron® (Bacterial Lysates Mixture)
9.6.2 Ribomunyl® (Bacterial Lysate Mixture)
9.6.3 Uro-Vaxom® (Bacterial Lysates)
9.6.4 SymbioLact® Compositum
9.7 Immune Enhancement Metabolites
9.7.1 Squalene
Bibliography
Reviews
Landmark Papers
Suggested Reading
10: Anti-allergy Medications
10.1 Introduction
10.2 Antihistamines
10.3 Prescription of Antihistamines in
Pregnant Women
10.4 Membrane Stabilizers
10.5 Topical Corticosteroids
10.6 Calcineurin Inhibitors
10.7 Anti-leukotrienes
10.8 Monoclonal Antibodies
Bibliography
Reviews
Landmark Papers
Suggested Reading
11: Allergen-Specific Immunotherapy (ASIT)
11.1 Introduction
Bibliography
Reviews
Land Papers
Suggested Reading
Answers to
Quizzes
Chapter 1
Chapter 2
Chapter 3
Chapter 4
Chapter 5
Chapter 6
Chapter 7
Chapter 8
Chapter 9
Chapter 10
Chapter 11
Ongoing Individual Life of€the€Immune System (Afterword)


📜 SIMILAR VOLUMES


From Basic to Clinical Immunology
✍ Vladimir V. Klimov 📂 Library 📅 2019 🏛 Springer International Publishing 🌐 English

<p><p>This book fills a gap at the interface of fundamental and clinical immunology, and allergy. For many years, experts in fundamental immunology and physicians involved in clinical immunology and allergy worked separately – but the fundamental immunologists did not have medical qualifications and

From Basic Immunology to Immune-Mediated
✍ F. Di Rosa, V. Barnaba (auth.), Gianvito Martino, Luciano Adorini (eds.) 📂 Library 📅 1999 🏛 Springer-Verlag Mailand 🌐 English

This book covers the immunological and clinical aspects of central and peripheral nervous system inflammatory diseases characterized by myelin damage. Leading scientists in the field have summarized in short reviews the state of the art of neuroimmunology, with particular emphasis on basic aspects o

Basic and Clinical Tumor Immunology
✍ Osias Stutman (auth.), Ronald B. Herberman (eds.) 📂 Library 📅 1983 🏛 Springer US 🌐 English

<p>Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general onco­ logy textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often prelimi­ n

Testosterone: From Basic to Clinical Asp
✍ Alexandre Hohl (editor) 📂 Library 📅 2023 🏛 Springer 🌐 English

<p><span>Even though research on testosterone is increasing, there is still much controversy regarding its physiology and clinical use. This book provides a broad overview on testosterone, from its basic features to the most recent evidence of clinical applicability. In addition, specific conditions

Testosterone: From Basic to Clinical Asp
✍ Alexandre Hohl (editor) 📂 Library 📅 2023 🏛 Springer 🌐 English

<p><span>Even though research on testosterone is increasing, there is still much controversy regarding its physiology and clinical use. This book provides a broad overview on testosterone, from its basic features to the most recent evidence of clinical applicability. In addition, specific conditions