From Basic Immunology to Immune-Mediated Demyelination

✍ Scribed by F. Di Rosa, V. Barnaba (auth.), Gianvito Martino, Luciano Adorini (eds.)

Publisher: Springer-Verlag Mailand
Year: 1999
Tongue: English
Leaves: 326
Series: Topics in Neuroscience
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

This book covers the immunological and clinical aspects of central and peripheral nervous system inflammatory diseases characterized by myelin damage. Leading scientists in the field have summarized in short reviews the state of the art of neuroimmunology, with particular emphasis on basic aspects of the regulation of immune responses during demyelinating disorders. The volume will be helpful to neuroimmunologists, but also to clinicians which will find a clear and concise understanding of the main features of neuroinflammatory disease.

✦ Table of Contents

Front Matter....Pages I-XIV
Protective Versus Harmful Responses and Immune Regulation....Pages 1-6
Antigen Recognition and Autoimmunity....Pages 7-15
Assembly and Function of Immunoglobulins During B Cell Development....Pages 16-25
Pathogenetic Mechanisms of Autoimmunity....Pages 26-37
Adhesion Receptors Involved in Leukocyte Functions....Pages 38-46
The Endothelium of the Brain Microvasculature and the Organization of Intercellular Junctions....Pages 47-57
Chemokines and Chemokine Receptors....Pages 58-67
Th1/Th2 Cytokine Network....Pages 68-82
Lymphocyte Trafficking in the Central Nervous System....Pages 83-88
Antigen Presentation in the Central Nervous System....Pages 89-100
Myelination of the Central Nervous System....Pages 101-115
Genomic Screening in Multiple Sclerosis....Pages 116-129
MHC and Multiple Sclerosis....Pages 130-136
Cytokine Genes in Multiple Sclerosis....Pages 137-148
Adhesion Molecules and the Blood-Brain Barrier in Multiple Sclerosis....Pages 149-161
Non-Myelin Antigen Autoreactivity in Multiple Sclerosis....Pages 162-169
Myelin Antigen Autoreactivity in Multiple Sclerosis....Pages 170-184
Inflammation and Multiple Sclerosis: a Close Interplay....Pages 185-194
Magnetic Resonance and Blood-Brain Barrier Dysfunction in Multiple Sclerosis....Pages 195-209
Immunotherapies for Multiple Sclerosis....Pages 210-232
Animal Models of Demyelination of the Central Nervous System....Pages 233-245
MHC and Non-MHC Genetics of Experimental Autoimmune Encephalomyelitis....Pages 246-264
Genetics of Hereditary Neuropathies....Pages 265-273
Immunopathogenetic Role of Anti-Neural Antibodies in Demyelinating Dysimmune Neuropathies....Pages 274-286
Treatment of Inflammatory Demyelinating Polyneuropathy....Pages 287-311
Back Matter....Pages 313-315

✦ Subjects

Immunology; Neurosciences; Neurology

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