Frodo proteins: modulators of Wnt signaling in vertebrate development
โ Scribed by Barbara K. Brott; Sergei Y. Sokol
- Book ID
- 115111389
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 956 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0301-4681
No coin nor oath required. For personal study only.
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Wnt signaling regulates many aspects of vertebrate development and adult stem cells. Deregulation of Wnt signaling causes development defect and cancer. The signaling is categorized in two pathways: canonical and noncanonical. Both pathways are initiated by Wnt ligands and Frizzled receptors. Canoni
## Abstract In the past twenty years, secreted signaling molecules of the Wnt family have been found to play a central role in controlling embryonic development from hydra to human. In the developing vertebrate limb, Wnt signaling is required for limb bud initiation, early limb patterning (which is