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Friend virus-induced erythroleukemia and the multistage nature of cancer

✍ Scribed by Yaacov Ben-David; Alan Bernsteint

Book ID
119064088
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
449 KB
Volume
66
Category
Article
ISSN
0092-8674

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We have tested the effects of specific and nonspeeific immunostimulation on the spontaneous regression and recurrence of erythroleukemia induced by a strain of the Friend murine leukemia virus complex, ## RFV. Subcutaneous inoculation of mice with UV-irradiated allogeneic leukemic spleen cells (LSC

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## Abstract The genetic control of spontaneous regression of erythroleukemia was studied in parental and hybrid mice in which leukemia was induced by the regressing strain of Friend virus (RFV). Because in previous studies parental regressor mouse strains tested (N/PLCR, SIM, NIH Swiss) all had the

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## Abstract Infection of (C57BL/6 Γ— DBA/2)F~1~ (BDF~1~) mice with 2,500 FFU of Friend virus complex (FV) resulted in erythroleukemia followed by recovery, at which time virus could not be detected in the spleens of mice, and with splenomegaly (progressor mice) or without splenomegaly (regressor mic