Active immunotherapy of friend virus-induced erythroleukemia and its spontaneous regression

✍ Scribed by D. Hines; M. Dietz; M. A. Rich; P. Furmanski

• Book ID: 104660455
• Publisher: Springer-Verlag
• Year: 1978
• Tongue: English
• Weight: 620 KB
• Volume: 5
• Category: Article
• ISSN: 0340-7004
• DOI: 10.1007/bf00199201

✦ Synopsis

We have tested the effects of specific and nonspeeific immunostimulation on the spontaneous regression and recurrence of erythroleukemia induced by a strain of the Friend murine leukemia virus complex,

RFV. Subcutaneous inoculation of mice with UV-irradiated allogeneic leukemic spleen cells (LSC) protected against subsequent virus challenge. RFV-leukemic mice injected with L S C into subcutaneous BCG-primed sites had a significantly increased incidence of leukemia regression. When leukemic mice received BCG or L S C alone or normal allogeneie spleen cells (NSC) in place of L S C the incidence of regression was not different from that recorded in untreated controls. A single treatment of recently regressed mice with L S C given into

BCG-primed sites prolonged the diseasefree period, while L S C alone, BCG alone, or NSC had no such effect. Our data support an immunological basis for spontaneous regression of erythroleukemia and for maintenance of the regressed state. This system provides a model for testing the efficacy of immunotherapeutic protocols for maintenance of leukemia remission and tumor dormancy.