Friedreich's ataxia gene localized to chromosome 9
โ Scribed by John Hardy
- Book ID
- 118390544
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 140 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0166-2236
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๐ SIMILAR VOLUMES
Friedreich ataxia, a progressive neurodegenerative disorder, is an autosomal recessive disease with a carrier frequency of 1/110 in the United Kingdom. The pathophysiological basis for the disease is not known and the chromosomal location of the mutation remains unidentified. As part of an attempt t
In order to determine the regional localization of the Friedreich's ataxia (FA) gene on chromosome 9, the DNA probe DR47 (D9S5), which detects a restriction fragment length polymorphism (RFLP) in tight linkage with the disease, was hybridized in situ to metaphase chromosomes. Our results enable the