Regional localization by in situ hybridization of a human chromosome 9 marker tightly linked to the Friedreich's ataxia locus

✍ Scribed by Elena Raimondi; Antonella Antonelli; Albert J. Driesel; Massimo Pandolfo

• Publisher: Springer
• Year: 1990
• Tongue: English
• Weight: 345 KB
• Volume: 85
• Category: Article
• ISSN: 0340-6717
• DOI: 10.1007/bf00276338

✦ Synopsis

In order to determine the regional localization of the Friedreich's ataxia (FA) gene on chromosome 9, the DNA probe DR47 (D9S5), which detects a restriction fragment length polymorphism (RFLP) in tight linkage with the disease, was hybridized in situ to metaphase chromosomes. Our results enable the D9S5 locus to be assigned to the 9q12-q13 region, thus indicating that this is also the localization of the FA gene.