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Friedel–Crafts alkylation of natural amino acid-derived pyrroles with CF3-substituted cyclic imines

✍ Scribed by Shmatova, Olga I.; Shevchenko, Nikolay E.; Balenkova, Elizabeth S.; Röschenthaler, Gerd-Volker; Nenajdenko, Valentine G.


Book ID
120034096
Publisher
Royal Society of Chemistry
Year
2013
Tongue
English
Weight
246 KB
Volume
23
Category
Article
ISSN
0959-9436

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## Abstract A new enantioselective Brønsted acid‐catalyzed Friedel–Crafts reaction of indole with cyclic imines has been develeoped. This organocatalytic reaction provides for the first time optically active indolindolinone derivatives in high yields and with excellent enantioselectivities (up to 9