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Frequent Somatic Mutations ofhMSH3with Reference to Microsatellite Instability in Hereditary Nonpolyposis Colorectal Cancers

โœ Scribed by Yoshimitsu Akiyama; Naomi Tsubouchi; Yasuhito Yuasa


Book ID
115580533
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
143 KB
Volume
236
Category
Article
ISSN
0006-291X

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Mutations in MLH1 are more frequent than
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The microsatellite instability that is a feature of tumors in patients with hereditary nonpolyposis colorectal cancer (HNPCC) is a consequence of defective DNA mismatch repair. Mutations in the DNA mismatch repair genes MSH2 and MLH1 may account for up to 90% of HNPCC kindreds. Microsatellite instab