Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma
✍ Scribed by Morin, Ryan D.; Mendez-Lago, Maria; Mungall, Andrew J.; Goya, Rodrigo; Mungall, Karen L.; Corbett, Richard D.; Johnson, Nathalie A.; Severson, Tesa M.; Chiu, Readman; Field, Matthew; Jackman, Shaun; Krzywinski, Martin; Scott, David W.; Trinh, Diane L.; Tamura-Wells, Jessica; Li, Sa; Firme, Marlo R.; Rogic, Sanja; Griffith, Malachi; Chan, Susanna; Yakovenko, Oleksandr; Meyer, Irmtraud M.; Zhao, Eric Y.; Smailus, Duane; Moksa, Michelle; Chittaranjan, Suganthi; Rimsza, Lisa; Brooks-Wilson, Angela; Spinelli, John J.; Ben-Neriah, Susana; Meissner, Barbara; Woolcock, Bruce; Boyle, Merrill; McDonald, Helen; Tam, Angela; Zhao, Yongjun; Delaney, Allen; Zeng, Thomas; Tse, Kane; Butterfield, Yaron; Birol, Inanç; Holt, Rob; Schein, Jacqueline; Horsman, Douglas E.; Moore, Richard; Jones, Steven J. M.; Connors, Joseph M.; Hirst, Martin; Gascoyne, Randy D.; Marra, Marco A.
- Book ID
- 121449920
- Publisher
- Nature Publishing Group
- Year
- 2011
- Tongue
- English
- Weight
- 494 KB
- Volume
- 476
- Category
- Article
- ISSN
- 0028-0836
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## Background: Alterations of the p53 gene have been associated with the progression of certain human malignancies. to establish further the correlation between p53 gene alterations and progression of non-hodgkin's lymphomas (nhls), the authors analyzed both mutations and rearrangements of the p53
## Abstract Non‐Hodgkin lymphomas (NHLs) are characterized by chromosomal translocations that juxtapose loci encoding lymphoid antigen receptors with cellular proto‐oncogenes. These translocations are thought to arise from inaccurate processing of DNA breaks created during physiologic recombination