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Frequent loss of p53 codon 72 Pro variant in hepatitis C virus-positive carriers with hepatocellular carcinoma

✍ Scribed by Mónica Anzola; Nerea Cuevas; Mónica López-Martı́nez; Alberto Saiz; Juan José Burgos; Marian Martı́nez de Pancorbo

Book ID
117467710
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
136 KB
Volume
193
Category
Article
ISSN
0304-3835

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Effect of the codon 72 polymorphism (c.2
Effect of the codon 72 polymorphism (c.215G>C, p.Arg72Pro) in combination with somatic sequence variants in the TP53 gene on survival in patients with advanced ovarian carcinoma
✍ Yun Wang; Pedro Kringen; Gunnar B. Kristensen; Ruth Holm; Mark M.O. Baekelandt; 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 522 KB

This study was conducted to evaluate the frequency and prognostic impact of TP53 alterations stratified for the TP53 codon 72 polymorphism (c.215G4C, p.Arg72Pro) in a cohort of 109 patients with advanced ovarian carcinomas. TP53 sequence variants were observed in 80 of the 109 (73.4%) tumors and wer

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Effect of the codon 72 polymorphism (c.215G>C, p.Arg72Pro) in combination with somatic sequence variants in the TP53 gene on survival in patients with advanced ovarian carcinoma
✍ Yun Wang; Pedro Kringen; Gunnar B. Kristensen; Ruth Holm; Mark M.O. Baekelandt; 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 104 KB

The original article to which this Erratum refers was published in Human Mutation 24: 21-34 (2004). Using a newly developed method-Arrayed Primer Extension (APEX) and direct sequencing of exon 10 and 11 to reanalyze for TP53 sequence alterations-13 new mutations were identified. In addition, a few

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Hepatitis C virus infection associated with human hepatocellular carcinoma : Lack of correlation with p53 abnormalities in Caucasian patients
✍ Patrizia Pontisso; Claudio Belluco; Roberta Bertorelle; Lorena De Moliner; Luigi 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 111 KB 👁 3 views

## BACKGROUND. Several lines of evidence indicate that there is a close association between hepatitis C virus (HCV) infection and hepatocellular carcinoma (HCC). However, the role of the virus itself in the development of the disease is not yet well understood. ## METHODS. In liver samples from