Frequent loss of 11p13 and 11p15 loci in male germ cell tumours

✍ Scribed by Ragnhild A. Lothe; Nick Hastie; Ketil Heimdal; Sophie D. Fosså; Anna Elisabeth Stenwig; Anne-Lise Børresen

• Book ID: 102845464
• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 529 KB
• Volume: 7
• Category: Article
• ISSN: 1045-2257
• DOI: 10.1002/gcc.2870070206

✦ Synopsis

Deletions within the short arm of the human chromosome I I have been found to be involved in the genesis of several tumoun, including different urogenital neoplasms. We have studied 3 I male germ cell turnours ( I 9 seminomas and I2 nonseminomas), and observed loss of heterozygosity at I I p loci in 40% (I 2/30) of these tumoun [ 35% (9126) at I I p I 3 and 3 I % (8/26) at I IpIS]. Our data suggest that inactivation of one or more tumour suppressor genes on I Ip are involved in the genesis of testicular cancer. In addition, identification of the parental origin of the allelic losses revealed a paternal IOU in six patients and a maternal loss in one case. Genes Chrom Cancer 7:96-101 (1993). 0 1993 Wiley-Liss, Inc.