Frequent loss in chromosome 8p loci in liver cirrhosis accompanying hepatocellular carcinoma
โ Scribed by Yosuke Kishimoto; Goshi Shiota; Kouichirou Wada; Masayuki Kitano; Kentaro Nakamoto; Yoshinori Kamisaki; Takeaki Suou; Tadao Itoh; Hironaka Kawasaki
- Book ID
- 112498818
- Publisher
- Springer-Verlag
- Year
- 1996
- Tongue
- English
- Weight
- 552 KB
- Volume
- 122
- Category
- Article
- ISSN
- 1432-1335
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Hepatocellular carcinoma (HCC) is a common malignancy worldwide and highly associated with chronic virus-B or -C infection and cirrhosis. Molecular studies have shown high frequency of loss of heterozygosity (LOH) in some specific chromosome regions, but LOH on chromosome 9 in HCC has not been thoro
We investigated 24 hepatocellular carcinomas in Japan to find loss of heterozygosity with 15 polymorphic DNA markers that detect allelic losses at specific chromosome loci. Loss of heterozygosity on chromosomes lOq, 17p and 22q was detected in 3 of 12 (26%), 9 of 21 (43%) and 5 of 15 (33%) informati