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Loss of heterozygosity of the retinoblastoma gene in liver cirrhosis accompanying hepatocellular carcinoma

โœ Scribed by Kumiyo Ashida; Yosuke Kishimoto; Kentaro Nakamoto; Kouichirou Wada; Goshi Shiota; Yasuaki Hirooka; Yoshinori Kamisaki; Tadao Itoh; Hironaka Kawasaki


Publisher
Springer-Verlag
Year
1997
Tongue
English
Weight
881 KB
Volume
123
Category
Article
ISSN
1432-1335

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We investigated 24 hepatocellular carcinomas in Japan to find loss of heterozygosity with 15 polymorphic DNA markers that detect allelic losses at specific chromosome loci. Loss of heterozygosity on chromosomes lOq, 17p and 22q was detected in 3 of 12 (26%), 9 of 21 (43%) and 5 of 15 (33%) informati

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## Background: Hepatocellular carcinoma (hcc) is one of the most common human tumors in asia and africa. the molecular genetic changes involving both protooncogenes and tumor suppressor genes are known to be involved in hepatocarcinogenesis, but the roles of the known tumor suppressor genes in hepa

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## Abstract Abnormalities of the retinoblastoma (__Rb__) gene have been reported in some human cancers, including hepatocellular carcinomas (HCCs). We examined by Southern blotting the status of the __Rb__ gene in HCCs induced in rats in four experimental models. A low frequency of __Rb__ gene alte