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Frequent gene amplification and overexpression of decoy receptor 3 in glioblastoma

✍ Scribed by Yasuaki Arakawa; Osamu Tachibana; Mitsuhiro Hasegawa; Tadao Miyamori; Junkoh Yamashita; Yutaka Hayashi

Publisher
Springer-Verlag
Year
2004
Tongue
English
Weight
271 KB
Volume
109
Category
Article
ISSN
0001-6322

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Karyotype and nucleic acid analyses have been performed on glioblastoma-derived primary cell lines at early passages. Four out of five cell lines displayed a significant increase in copy number of epidermal growth factor (EGF) receptor gene, which was related to polisomy of chromosome 7, where the g