PIK3CA mutations in advanced ovarian car
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Yun Wang; Åslaug Helland; Ruth Holm; Gunnar B. Kristensen; Anne-Lise Børresen-Da
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Article
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2005
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John Wiley and Sons
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English
⚖ 151 KB
PIK3CA belongs to the phosphatidylinositol 3-kinases (PI3Ks) family, which play an important role in proliferation, adherence, transformation and cell survival through the PI3K/AKT signaling pathway. Somatic activating mutations of this gene have recently been detected in several types of cancers. I