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Frequent Activating Mutations of PIK3CA in Ovarian Clear Cell Carcinoma

✍ Scribed by Kuan-Ting Kuo; Tsui-Lien Mao; Siân Jones; Emanuela Veras; Ayse Ayhan; Tian-Li Wang; Ruth Glas; Dennis Slamon; Victor E. Velculescu; Robert J. Kuman; Ie-Ming Shih


Book ID
117970933
Publisher
American Society for Investigative Pathology
Year
2009
Tongue
English
Weight
109 KB
Volume
174
Category
Article
ISSN
0002-9440

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PIK3CA mutations in advanced ovarian car
✍ Yun Wang; Åslaug Helland; Ruth Holm; Gunnar B. Kristensen; Anne-Lise Børresen-Da 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 151 KB

PIK3CA belongs to the phosphatidylinositol 3-kinases (PI3Ks) family, which play an important role in proliferation, adherence, transformation and cell survival through the PI3K/AKT signaling pathway. Somatic activating mutations of this gene have recently been detected in several types of cancers. I