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Frequency of the fragile X syndrome in Chinese mentally retarded populations is similar to that in Caucasians

✍ Scribed by Zhong, Nan; Ju, Weina; Xu, Weimin; Ye, Lingling; Shen, Yan; Wu, Guangyun; Chen, Shi-han; Jin, Runming; Hu, Xiao-feng; Yang, Aide; Liu, Xixian; Poon, Priscilla; Pang, Calvin; Zheng, Yu; Song, Li; Zhao, Pei; Fu, Bojing; Gu, Hongjuan; Brown, W. Ted

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
17 KB
Volume
84
Category
Article
ISSN
0148-7299
DOI
10.1002/(sici)1096-8628(19990528)84:3<191::aid-ajmg3>3.0.co;2-8

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✦ Synopsis

Fragile X syndrome is recognized as the most common inherited cause of mental retardation in western countries. The prevalence of the fragile X syndrome in Asian populations is uncertain. We report a multi-institutional collaborative study of molecular screening for the fragile X syndrome from 1,127 Chinese mentally retarded (MR) individuals. We found that 2.8% of the Chinese MR population screened by DNA analysis had the fragile X full mutation. Our screening indicated that the fragile X syndrome prevalence was very close to that of Caucasian subjects. In addition, we found that 62.5% of fragile X chromosomes had a single haplotype for DXS548-FRAXAC1 (21-18 repeats) which was present in only 9.7% of controls. This unique distribution of microsatellite markers flanking the FMR1 CGG repeats suggests that the fragile X syndrome in Chinese populations, as in the Caucasian, may also be derived from founder chromosomes.

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