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Frequency of Fra X syndrome among institutionalized mentally retarded males in Poland

✍ Scribed by Mazurczak, Tadeusz; Bocian, Ewa; Milewski, Michal; Obersztyn, Ewa; Stánczak, Halina; Bal, Jerzy; Szamotulska, Katarzyna; Karwacki, Marek W.

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
20 KB
Volume
64
Category
Article
ISSN
0148-7299

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✦ Synopsis

Results of cytogenetic studies, performed in a group of 201 institutionalized mentally retarded males, are presented. At least two cytogenetic methods for eliciting the Xq27.3 fragile site, recommended by the Fourth International Workshop on the Fra X Syndrome were used. A subgroup of 67 out of 201 studied males was also examined using molecular methods. In 6 (2.9%) males fra X syndrome was diagnosed. All cytogenetic positive results were confirmed by molecular analysis. Five patients had full expansion CGG repeats and one had both premutation and full mutation. Postulated frequency of fra X syndrome in Polish population being 0.2-0.4/1,000 males seems to be lower than it could be expected on the basis of previous literature data.

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