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Frequency and types of deletional α+in Northern Sardinia

✍ Scribed by Anna Rienzo; Luciano Felicetti; Andrea Novelletto; Gavino Forteleoni; Bruno Colombo

Publisher
Springer
Year
1985
Tongue
English
Weight
278 KB
Volume
71
Category
Article
ISSN
0340-6717

No coin nor oath required. For personal study only.

✦ Synopsis

We determined by restriction mapping the frequency of the -alpha 3.7 determinant in a random sample of 48 adults in Northern Sardinia. We found a frequency of 0.18 +/- 0.04 and demonstrated that only type I crossover as determined by Apa I digestion (Higgs et al. 1984) is present. Moreover, we showed that this haplotype is not associated with an Rsa I polymorphism 5' to the alpha 2-globin gene. These data support the hypothesis of a unique origin of this deletion in Sardinia.

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