DNA was prepared from tumour and normal tissue from 48 patients representing all common histological types of nonsmall-cell lung cancer. Using eight DNA probes, which detect nine restriction enzyme fragment length polymorphisms (RFLP) on chromosome 3, we established that among the 44 informative pat
Frequency and extent of allelic loss in the short arm of chromosome 3 in nonsmall-cell lung cancer
- Book ID
- 122673265
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 156 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0169-5002
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## Background: An accumulation of mutations can result in carcinogenesis. comparing genetic alterations in preneoplastic lesions with those seen in cancer in the same patient may be helpful in the early diagnosis of lung carcinoma or preneoplastic lesions. ## Methods: To identify genetic alterati