Frequency and distribution of sister-chromatid exchanges in a case of Fanconi's anemia
โ Scribed by K. Sperling; R.-D. Wegner; H. Riehm; G. Obe
- Publisher
- Springer
- Year
- 1975
- Tongue
- English
- Weight
- 361 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0340-6717
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โฆ Synopsis
In lymphocytes of a 7-year-old boy with Fanconi's anemia the frequencies and sites of sister-chromatid exchanges (SCE) were studied with the BrdU-Giemsa method. The average frequency of SCE (8.8 per metaphase) and the inter- and intrachromosomal distribution of SCE was not significantly different from the controls.
๐ SIMILAR VOLUMES
A model of the sister chromatid exchange (SCE) process is outlined as a replication mechanism to bypass DNA crosslinks. The model suggests that when normal bidirectional replication advances from both sides towards a crosslink along the two opposite parental strands, the complementary parental stran
The effect of cigarette smoking on the frequency of sister chromatid exchanges (SCE'S) was investigated in a group of adult men. It was observed that there was a significant increase in the mean SCE frequency per cell in smokers. Both the duration of smoking and the number of cigarettes smoked per d
Lymphocytes from 20 notmal subjects (11 male and 9 female) were examined for the frequency and location of sister chromatid exchanges (SCE) by the BrdU--Giemsa method. The mean frequency of SCE was 6.37 with little significant variation. One subject had a high number of exchanges in chromosome 1 whi