In lymphocytes of a 7-year-old boy with Fanconi's anemia the frequencies and sites of sister-chromatid exchanges (SCE) were studied with the BrdU-Giemsa method. The average frequency of SCE (8.8 per metaphase) and the inter- and intrachromosomal distribution of SCE was not significantly different fr
โฆ LIBER โฆ
Failure of diepoxybutane to enhance sister chromatid exchange levels in Fanconi's anemia patients and heterozygotes
โ Scribed by B. Porfirio; B. Dallapiccola; V. Mokini; Giuliana Alimena; E. Gandini
- Publisher
- Springer
- Year
- 1983
- Tongue
- English
- Weight
- 444 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0340-6717
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The incidence of structural chromosome aberrations and the rate of sister chromatid exchanges (SCE) was investigated in lymphocyte cultures from a patient with typical Fanconi's anemia and his parents. The rate of SCEs was found to be normal. In experiments with the alkylating agent Trenimon the SCE