Free radicals in iron depletion of human ferritin.
โ Scribed by Dan Gelvan; Abraham M. Konijn
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 91 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0162-0134
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Iron storage proteins, ferritin and haemosiderin, release iron to a range of chelators and reducing agents, including citrate, acetate and ascorbate. Released iron promotes both hydroxyl radical formation in the presence of hydrogen peroxide and lipid peroxidation in fiposomes. Ferritin protein is m
The expressions of transferrin receptor and ferritin in a human-human hybridoma in protein-free media were examined. The regulation of the expressions of the two proteins appeared to be decoupled in protein-free cultures. Such cultures also exhibited much higher ferritin expression and endogenous ir