𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Ferritin and haemosiderin in free radical generation, lipid peroxidation and protein damage

✍ Scribed by M.J. O'Connell; T.J. Peters

Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
863 KB
Volume
45
Category
Article
ISSN
0009-3084

No coin nor oath required. For personal study only.

✦ Synopsis

Iron storage proteins, ferritin and haemosiderin, release iron to a range of chelators and reducing agents, including citrate, acetate and ascorbate. Released iron promotes both hydroxyl radical formation in the presence of hydrogen peroxide and lipid peroxidation in fiposomes. Ferritin protein is modified in such reactions, both by free radical cleavage and addition reactions with aldehyde products of lipid peroxidation.

📜 SIMILAR VOLUMES

Exercise-induced lipid peroxidation: Imp
Exercise-induced lipid peroxidation: Implications for deoxyribonucleic acid damage and systemic free radical generation
✍ Mark C. Fogarty; Ciara M. Hughes; George Burke; John C. Brown; Tom R. Trinick; E 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 374 KB

## Abstract Exercise‐induced deoxyribonucleic acid (DNA) damage is often associated with an increase in free radicals; however, there is a lack of evidence examining the two in parallel. This study tested the hypothesis that high‐intensity exercise has the ability to produce free radicals that may

Allergy to drugs: antioxidant enzymic ac
Allergy to drugs: antioxidant enzymic activities, lipid peroxidation and protein oxidative damage in human blood
✍ José M. Matés; Cristina Pérez-Gómez; Lucia Olalla; José M. Segura; Miguel Blanca 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 126 KB 👁 2 views

Reactive oxygen species lead to lipid peroxidation and speci®c oxidation of some speci®c enzymes, proteins and other macromolecules, thus aecting many intra-and intercellular systems. Recently, antioxidant functions have been linked to anti-in¯ammatory properties. Cell defences against toxic oxygen

Relationship of oxygen radical-induced l
Relationship of oxygen radical-induced lipid peroxidative damage to disease onset and progression in a transgenic model of familial ALS
✍ Edward D. Hall; Paula K. Andrus; Jo A. Oostveen; Timothy J. Fleck; Mark E. Gurne 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 552 KB

Transgenic mice that overexpress a mutated human CuZn superoxide dismutase (SOD1) gene (gly 93 =ala) found in some patients with familial ALS (FALS) have been shown to develop motor neuron disease, as evidenced by motor neuron loss in the lumbar and cervical spinal regions and a progressive loss of

Oxidative damage to proteins and lipids
Oxidative damage to proteins and lipids of CNS myelin produced by in vitro generated reactive oxygen species
✍ E. R. Bongarzone; J. M. Pasquini; E. F. Soto 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 857 KB

## Abstract Purified myelin isolated from 70‐day‐old rats was submitted to nonenzymatic peroxidative systems containing 100 μM FeC1~3~.6H~2~O,100 μM ascorbic acid, and 100 μM CuSO~4~.6H~2~O 10 mM H~2~O~2~ in order to investigate the extent of damage produced by reactive oxygen species (ROS). Iron a