Free radical reactions for heterocycle synthesis. Part 4: A double ipso substitution reaction for azacoumarins
β Scribed by Wei Zhang; Georgia Pugh
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 91 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
Novel bridged spirolactones have been synthesized via double radical cyclization of enol ester radicals.
Synthesis of spirodilactones is achieved by intramolecular free radical Michael addition of enol esters derivatized from tetronic acid. Synthesis of spirolactone-lactams and spirolactone-thiolactones is also covered by the scope of this new reaction.
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